Polyclonal Antibody against Eps15 (C-term)
Polyclonal Antibody against Eps15 (C-term)是一種靶向蛋白C末端區域(yu)的多克(ke)隆抗體產品,通過(guo)特异性识
Polyclonal Antibody against Eps15 (C-term) 是一款(kuan)针(zhen)對内吞作用相關蛋白 Eps15 羧(suo)基末端區域
產品编號： PRB-124C
產品价格： 詢价
產品產地： USA
品牌商標： COVANCE
更新時間： 2024-12-10T13:22:33
使用範围：
翌圣生物科(ke)技（上海）股份有限公司
- 聯系人 : 馬贞美
- 地址 : 上海市浦(pu)东新區(qu)天雄路166弄一號楼三層南(nan)單元
- 郵编 : 200030
- 所在區域 : 上海
- 電話 : 139****5640 點擊查看
- 傳真 : 點擊查看
- 郵箱 : [email protected]
- 二維碼 : 點擊查看
| Description |  |
Polyclonal Antibody against Eps15 (C-term) |
| Form | |
Antiserum |
| Host | |
Rabbit |
| Species Reactivity | |
Human, Mouse |
| Specificity | |
The eps15 protein (EGFR pathway substrate clone 15) is tyrosine phosphorylated by the activation of the EGF and PDGF receptors. It was first identified as an 896 amino acid protein in mouse. Subsequent cloning of the human protein showed 90% homology to the mouse form. Several physiological functions have been proposed for eps15. Phosphorylation of EGF and PDGF receptors indicates that eps15 plays a role in signal transduction, cell proliferation and endocytosis. This antibody was generated against a recombinant protein containing the C-termnial sequence of Eps15 (amino acids 539-896). |
| Uses | |
This antibody is effective in immunoblotting, immunoprecipitation and immunoelectron microscopy. |
| Suggested Working Dilution | |
The optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval.
|
| Notes | |
*Predicted MW = 145 kD |
| Storage | |
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C. |
| References | |
Cupers P, ter Haar E, Boll W, Kirchhausen T. Parallel dimers and anti-tetramers formed by epidermal growth factor receptor pathways substrate clone 15 (Eps15). J. Biol. Chem. 272(52):33430-33434, 1997. Tebar F, Confalionieri S, Carter RE, Di Fiore PP, Sorkin A. Eps15 is constitutively oligomerized due to homophilic interaction of its coiled-coil region. J. Biol. Chem. 272:15341-15347, 1997. Benmerah A, Gagnon J, Begue B, Megarbane B, Dautry-Varsat A, Cerf-Besussan N. The tyrosine kinase substrate eps15 is constitutively associated with the plasma membrane adaptor AP-2. J. Cell Biol. 131:1831-1838, 1995. Fazioli FL, Minichiello B, Mtoskova W, Wong T, Di Fiore PP. Eps15, a novel tyrosine kinase substrate, exhibits transforming activity. Mol. Cell. Biol. 13:5814-5828, 1993. |
| Warranty/Conditions | |
Covance products may not be resold or modified for resale without prior written approval. |
| Rev. Date | |
8/21/2006 |